N,N-Dimethylformamide CAS#68-12-2

Versatile Solvent:Dimethylformamide (DMF) dissolves in both water and organic solvents, making it highly adaptable for use across a variety of chemical processes.


Industrial Applications:Widely employed in the production of acrylic fibers, pharmaceuticals, dyes, petroleum products, and other organic chemicals.


Specialized Uses:Functions as a gasoline additive and is also utilized in electronics manufacturing, highlighting its utility in multiple technical fields.


Efficient Physical Properties:With a boiling point of 153°C, low freezing point of -61°C, and moderate vapor pressure, DMF is convenient for high-temperature reactions and industrial processes requiring stable liquid solvents.


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Product Description

Products Description of N,N-Dimethylformamide CAS#68-12-2

N,N-Dimethylformamide (DMF) is a colorless, flammable liquid with a characteristic fishy odor. It has a molecular weight of 73.11, a boiling point of 153°C, a freezing point of -61°C, a flash point of 58°C, and a vapor pressure of 3 mmHg at 20°C. DMF is soluble in both water and a wide range of organic solvents. It presents hazards including flammability (explosive limits: LEL 2.2%, UEL 15.2%), toxicity, carcinogenicity, mutagenicity, and potential for skin irritation. It is extensively used as a solvent in the production of acrylic fibers, pharmaceuticals, dyes, petroleum products, and other organic chemicals, and also finds applications as a gasoline additive and in electronic manufacturing.


Product Application of N,N-Dimethylformamide CAS#68-12-2

N,N-Dimethylformamide (DMF) is primarily used as a solvent and extractant, especially for salts and high-molecular-weight compounds. Its versatility stems from a unique combination of physical and chemical properties, including low molecular mass, high dielectric constant, electron-donor capability, and complex-forming ability. Although its role as a reagent in chemical synthesis is less commercially significant, anhydrous DMF has been employed as a solvent in the preparation of cytotoxic luteinizing hormone-releasing hormone (LH-RH) conjugate AN-152 (a chemotherapeutic agent) and the fluorophore C625 [4-(N,N-diphenylamino)-4′-(6-O-hemiglutarate)hexylsulfinyl stilbene]. It also serves as a solvent medium in various organic reduction reactions.


Product Information

Parameters


Melting point-61 °C (lit.)
alpha0.94 º
Boiling point153 °C (lit.)
density0.944 g/mL (lit.)
vapor density2.5 (vs air)
vapor pressure2.7 mm Hg ( 20 °C)
refractive indexn20/D 1.430(lit.)
Fp136 °F
storage temp.Store at +5°C to +30°C.
solubilitywater: miscible
pka-0.44±0.70(Predicted)
formliquid
colorAPHA: ≤15
PH7 (200g/l, H2O, 20℃)
OdorFaint, ammonia-like odor detectable at 100 ppm
Relative polarity0.386
Odor Threshold1.8ppm
explosive limit2.2-16%(V)
Water Solubilitysoluble
λmaxλ: 270 nm Amax: 1.00
λ: 275 nm Amax: 0.30
λ: 295 nm Amax: 0.10
λ: 310 nm Amax: 0.05
λ: 340-400 nm Amax: 0.01
SensitiveHygroscopic
Merck143243
BRN605365
Exposure limitsNIOSH REL: TWA 10 ppm (30 mg/m3), IDLH 500 ppm; OSHA PEL: TWA 10 ppm; ACGIH TLV: TWA 10 ppm (adopted).
Dielectric constant36.71
InChIKeyZMXDDKWLCZADIW-UHFFFAOYSA-N
LogP-1.01
Surface tension35.20mN/m at 298.15K
Surface tension37.1mN/m at 20°C
CAS DataBase Reference68-12-2(CAS DataBase Reference)
NIST Chemistry ReferenceFormamide, N,N-dimethyl-(68-12-2)
IARC2A (Vol. 47, 71, 115) 2018
EPA Substance Registry SystemN,N-Dimethylformamide (68-12-2)


Safety Information


Hazard CodesT
Risk Statements61-20/21-36
Safety Statements53-45
RIDADRUN 2265 3/PG 3
OEBA
OELTWA: 10 ppm (30 mg/m3) [skin]
WGK Germany1
RTECSLQ2100000
F46091
Autoignition Temperature445 °C
Hazard NoteToxic
TSCAYes
HazardClass3
PackingGroupIII
HS Code29241990
Hazardous Substances Data68-12-2(Hazardous Substances Data)
ToxicityLD50 in mice, rats (ml/kg): 6.8, 7.6 orally; 6.2, 4.7 i.p. (Bartsch)
IDLA500 ppm



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