Ketoconazole CAS#65277-42-1

Broad-Spectrum Antifungal Activity:Ketoconazole is an imidazole antifungal effective against a wide range of fungal infections, including superficial and deep mycoses.


Selective Inhibition of Ergosterol BiosynthesisIt blocks ergosterol synthesis by interfering with fungal cytochrome P-450, disrupting cell membranes and preventing fungal growth.


Prevention of Fungal Growth and Spore TransformationKetoconazole inhibits fungal growth and prevents spores from forming mycelium, reducing reinfection risk.


Antibacterial and Clinical VersatilityIt acts against Candida, Coccidioides, Histoplasma, Sporothrix, and Trichophyton, and is used to treat tinea pedis, tinea corporis, tinea cruris, thrush, and skin candidiasis.



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Product Description

Product Description of Ketoconazole CAS#65277-42-1

Ketoconazole is a broad-spectrum imidazole antifungal agent. It inhibits fungal cytochrome P450 to block ergosterol synthesis and damage fungal cell membranes. It suppresses fungal proliferation and spore development, exerting bacteriostatic and bactericidal effects. Effective against various fungi, it is widely used for treating multiple superficial and systemic fungal skin and mucosal infections.


Product Application of Ketoconazole CAS#65277-42-1

Ketoconazole is a broad-spectrum imidazole antifungal for various fungal infections including tinea pedis, candidiasis and systemic mycoses. As a CYP3A4 inhibitor, it is also widely used in pharmacological research for bioavailability assessment, antitumor study and drug interaction analysis.

Product Information

Parameters


Melting point148-152 °C
Boiling point753.4±60.0 °C(Predicted)
density1.4046 (rough estimate)
refractive index-10.5 ° (C=0.4, CHCl3)
Fp9℃
storage temp.2-8°C
solubilitymethanol: soluble50mg/mL
pkapKa 3.25/6.22(H2O,t =25,I=0.025) (Uncertain)
formOff-white solid
colorwhite to light yellow
optical activity[α]20/D -1 to 1°, c = 4 in methanol
Water SolubilitySoluble in DMSO, ethanol, chloroform, water, and methanol.
Merck145302
BCS Class2
Stability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKeyXMAYWYJOQHXEEK-OZXSUGGESA-N
LogP4.35
CAS DataBase Reference65277-42-1(CAS DataBase Reference)


Safety Information


Hazard CodesT,N,F
Risk Statements25-36/37/38-23/24/25-50/53-48/22-60-39/23/24/25-11
Safety Statements36-45-36/37/39-26-61-60-53-36/37-16-7
RIDADRUN 2811 6.1/PG 3
WGK Germany3
RTECSTK7912300
HazardClass6.1(b)
PackingGroupIII
HS Code29349990
Hazardous Substances Data65277-42-1(Hazardous Substances Data)
ToxicityLD50 in mice, rats, guinea pigs, dogs (mg/kg): 44, 86, 28, 49 i.v.; 702, 227, 202, 780 orally (Heel)


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Q1: Is Huafeng Chemical a manufacturer or a trader?
A: We are a professional service provider specializing in chemical foreign trade. Rather than being limited to the products of a single factory, we leverage the chemical industry cluster in Shandong Province to integrate production resources from multiple high-quality manufacturers. This allows us to offer a wide range of sourcing options—covering various product categories and origins—instead of simply pushing a single product. Furthermore, our core competitiveness lies in our professional foreign trade services (covering documentation, logistics, and regulatory compliance), ensuring a smooth and worry-free procurement process for you.


Q2: How is the security of my transaction guaranteed when working with Huafeng Chemical?
A: We strictly adhere to international trade rules (Incoterms® 2020) and accept various payment methods, such as Letters of Credit (L/C) and Telegraphic Transfers (T/T). For new clients, we support small-batch trial orders and can clearly define arbitration clauses and applicable laws within the contract. Additionally, we maintain a robust risk management system to help you mitigate common trade risks, such as exchange rate fluctuations, shipping delays, and document discrepancies.


Q3: Do you have experience serving clients in Russian-speaking regions?
A: Yes. We place great importance on the Russian-speaking market; our team includes Russian-speaking business professionals who are well-versed in the import regulations of Russia and the Eurasian Economic Union (EAEU). We understand the importance of EAC certification to clients in these regions and can assist with related compliance inquiries. We have established connections with chemical traders across various CIS countries and have gained valuable experience in specialized packaging and temperature-controlled shipping designed to withstand harsh local winter conditions.


Q4: How do you guarantee product quality?
A: We implement a strict supplier qualification and periodic audit system. A Certificate of Analysis (COA)—issued by the original manufacturer—is provided with every shipment. We also welcome pre-shipment inspections conducted by internationally recognized third-party agencies such as SGS, BV, or ITS. Should the test results fail to meet the standards specified in the contract, you have the right to reject the goods or request a replacement.

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