Methyl acetoacetate CAS#105-45-3

Versatile Synthetic Reagent: Widely used in pharmaceutical synthesis and various organic reactions.


Key Role in Named Reactions: Participates in the Biginelli reaction, enabling the formation of valuable dihydropyrimidinone compounds.


Broad Derivative Formation: Supports the synthesis of diverse compounds such as pyrazole, pyrimidine, and coumarin derivatives.


Flexible Chemical Functionality: Suitable for producing α-substituted acetoacetic esters and cyclic structures, enhancing application versatility.



Phone :+86 13165319682
WhatsApp :+86 13165319682
Email :admin@sdhf-chemical.com
Send Inquiry →

Product Description

Product Description of Methyl acetoacetate CAS#105-45-3

Methyl acetoacetate is a chemical reagent widely used in pharmaceutical synthesis. It participates in the Biginelli reaction, enabling the formation of compounds such as dihydropyrimidinones. In addition, methyl acetoacetate (MAA) is utilized in the preparation of α-substituted acetoacetic esters and various cyclic compounds, including pyrazole, pyrimidine, and coumarin derivatives.


Product Application of Methyl acetoacetate CAS#105-45-3

Methyl acetoacetate (MAA) is used in a variety of applications. It serves as a chemical reagent in organic synthesis and can also function as a solvent for cellulose ethers. It is utilized as an intermediate in the preparation of organic compounds, including the synthesis of nifedipine. In addition, it is applied as a food additive, acting as an amine-protecting agent for synthetic sweeteners. MAA is also used as a pharmaceutical raw material in the production of antibiotics.


Product Information

Parameters


Melting point-80 °C (lit.)
Boiling point169-170 °C/70 mmHg (lit.)
density1.076 g/mL at 25 °C (lit.)
vapor density4 (vs air)
vapor pressure1 hPa (20 °C)
refractive indexn20/D 1.419(lit.)
Fp158 °F
storage temp.2-8°C
solubility460 g/L (20°C)
pka10.67±0.46(Predicted)
formLiquid
colorAPHA: ≤20
Odorat 100.00 %. fresh fruity citrus green
PH3.8 (863g/l, H2O, 20℃)
Odor Typefruity
explosive limit1.3-14.2%(V)
Water Solubility460 g/L (20 ºC)
Merck146009
BRN506727
Cosmetics Ingredients FunctionsPERFUMING
InChI1S/C5H8O3/c1-4(6)3-5(7)8-2/h3H2,1-2H3
InChIKeyWRQNANDWMGAFTP-UHFFFAOYSA-N
SMILESCOC(=O)CC(C)=O
LogP0.185 (est)
CAS DataBase Reference105-45-3(CAS DataBase Reference)
NIST Chemistry ReferenceButanoic acid, 3-oxo-, methyl ester(105-45-3)
EPA Substance Registry SystemMethyl acetoacetate (105-45-3)


Safety Information


Hazard CodesXi
Risk Statements36
Safety Statements26
RIDADRNA1993
WGK Germany1
RTECSAK5775000
Autoignition Temperature536 °F
TSCATSCA listed
HazardClassCBL
HS Code29183000
Storage Class10 - Combustible liquids
Hazard ClassificationsEye Dam. 1
Hazardous Substances Data105-45-3(Hazardous Substances Data)
ToxicityLD50 orally in rats: 3.0 g/kg (Smyth, Carpenter)


Factory Showcase

拼图_美图设计室-(1)

Quality Control Lab

实验室

Shipping And Transportation

拼图_美图设计室

FAQ

Q1: Is Huafeng Chemical a manufacturer or a trader?
A: We are a professional service provider specializing in chemical foreign trade. Rather than being limited to the products of a single factory, we leverage the chemical industry cluster in Shandong Province to integrate production resources from multiple high-quality manufacturers. This allows us to offer a wide range of sourcing options—covering various product categories and origins—instead of simply pushing a single product. Furthermore, our core competitiveness lies in our professional foreign trade services (covering documentation, logistics, and regulatory compliance), ensuring a smooth and worry-free procurement process for you.


Q2: How is the security of my transaction guaranteed when working with Huafeng Chemical?
A: We strictly adhere to international trade rules (Incoterms® 2020) and accept various payment methods, such as Letters of Credit (L/C) and Telegraphic Transfers (T/T). For new clients, we support small-batch trial orders and can clearly define arbitration clauses and applicable laws within the contract. Additionally, we maintain a robust risk management system to help you mitigate common trade risks, such as exchange rate fluctuations, shipping delays, and document discrepancies.


Q3: Do you have experience serving clients in Russian-speaking regions?
A: Yes. We place great importance on the Russian-speaking market; our team includes Russian-speaking business professionals who are well-versed in the import regulations of Russia and the Eurasian Economic Union (EAEU). We understand the importance of EAC certification to clients in these regions and can assist with related compliance inquiries. We have established connections with chemical traders across various CIS countries and have gained valuable experience in specialized packaging and temperature-controlled shipping designed to withstand harsh local winter conditions.


Q4: How do you guarantee product quality?
A: We implement a strict supplier qualification and periodic audit system. A Certificate of Analysis (COA)—issued by the original manufacturer—is provided with every shipment. We also welcome pre-shipment inspections conducted by internationally recognized third-party agencies such as SGS, BV, or ITS. Should the test results fail to meet the standards specified in the contract, you have the right to reject the goods or request a replacement.

Contact Us

Submit

Recommendation