Progesterone CAS#57-83-0

Natural Endogenous Progestogen Hormone:Progesterone is the body’s primary naturally occurring progestogen, secreted by the ovarian luteal cells, ensuring excellent biological relevance and compatibility.


Key Steroid Hormone IntermediateIt serves as an important intermediate for the synthesis of all steroid hormones, making it highly valuable in pharmaceutical and hormone-related applications.


Dual Crystal Forms with Identical ActivityAvailable in both α-type and β-type crystal forms, both providing the same physiological activity for flexible formulation use.


Excellent Solvent CompatibilityAlthough insoluble in water, progesterone is readily soluble in ethanol, ether, chloroform, acetone, dioxane, and concentrated sulfuric acid, supporting diverse processing and formulation requirements.



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Product Description

Products Description of Progesterone CAS#57-83-0

Progesterone is an endogenous steroid hormone mainly secreted by ovaries, acting as a major natural progestogen and key intermediate for steroid hormone synthesis.

It has two crystal forms with identical bioactivity. Insoluble in water, it dissolves readily in most organic solvents and concentrated sulfuric acid.


Product Application of Progesterone CAS#57-83-0

Progesterone cooperates with estrogen to transform endometrium for embryo implantation, maintains pregnancy by restraining uterine contraction, and facilitates breast development for lactation. High doses suppress ovulation via hormonal feedback.

It is clinically applied to treat threatened abortion, irregular bleeding, dysmenorrhea, amenorrhea and other gynecological disorders, as well as prostatic hyperplasia and related complications.


Product Information

Parameters


Melting point128-132 °C (lit.)
alpha186 º (c=1, ethanol)
Boiling point394.13°C (rough estimate)
densityd23 1.166; d20 1.171
refractive index182 ° (C=2, Dioxane)
Fp2℃
storage temp.room temp
solubilityH2O: 25 mg/mL, may be clear to slightly hazy
formpowder
colorYellow to yellow-brown
biological sourcesynthetic (organic)
Water Solubility<0.1 g/100 mL at 19 ºC
Merck7773
BRN1915950
BCS Class4
Stability:Stable. Incompatible with strong oxidizing agents.
InChIKeyRJKFOVLPORLFTN-LEKSSAKUSA-N
LogP3.87
CAS DataBase Reference57-83-0(CAS DataBase Reference)
NIST Chemistry ReferenceProgesterone(57-83-0)
EPA Substance Registry SystemProgesterone (57-83-0)


Safety Information


Hazard CodesXn,T,F
Risk Statements40-45-62-36-20/21/22-11
Safety Statements36/37-45-53-16
RIDADRUN 1648 3 / PGII
WGK Germany3
RTECSTW0175000
HS Code29372390
Hazardous Substances Data57-83-0(Hazardous Substances Data)
ToxicityLD50 intraperitoneal in rat: 327mg/kg









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