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Curcumin CAS#458-37-7
Powerful Antioxidant：Curcumin prevents oxidative stress by inhibiting nitric oxide (NO) production and reducing markers of oxidative damage, such as 3-nitrotyrosine (3-NT).
Strong Anti-Inflammatory Activity：It suppresses the release of histamine and inflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8), reducing inflammation in both cellular and animal models.
Antitumor Effects：Curcumin decreases tumor formation in mouse skin and reduces the number of preneoplastic lesions and neoplasms in animal models.
Protective in Allergic and Cardiovascular Conditions：It mitigates histopathological changes in nasal mucosa, reduces symptoms of rhinitis, and shows protective effects against cardiovascular oxidative stress.
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Product Description of Curcumin CAS#458-37-7
Curcumin is the primary yellow pigment found in turmeric and curry, known for its antioxidant, anti-inflammatory, and antitumor properties. It effectively inhibits nitric oxide (NO) production (IC50 = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells. Curcumin also suppresses the release of histamine and inflammatory cytokines, including TNF-α, IL-1β, IL-6, and IL-8, from HMC-1 mast cells.
In vivo studies show that curcumin lowers serum levels of histamine and TNF-α, prevents histopathological changes in the nasal mucosa, and reduces sneezing and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Additionally, curcumin (100 or 200 mg/kg) inhibits the accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in the hearts of mice. Topical application (1–10 μmol) decreases the number of tumors induced by phorbol 12-myristate 13-acetate (TPA) in mouse skin, while dietary administration reduces tongue neoplasms and preneoplastic lesions caused by 4-nitroquinoline 1-oxide (4-NQO) in rats.
Product Application of Curcumin CAS#458-37-7
Curcumin is a natural phenolic compound with potent anti-tumor, anti-inflammatory, and antioxidant properties. It induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Curcumin has been reported to suppress the production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. It is a strong inhibitor of EGFR tyrosine kinase and IκB kinase, and also inhibits inducible nitric oxide synthase (iNOS), cyclooxygenase, and lipoxygenase.
Curcumin readily penetrates the cytoplasm of cells, accumulating in membranous structures such as the plasma membrane, endoplasmic reticulum, and nuclear envelope, enhancing its biological activity.
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Q1: Is Huafeng Chemical a manufacturer or a trader?
A: We are a professional service provider specializing in chemical foreign trade. Rather than being limited to the products of a single factory, we leverage the chemical industry cluster in Shandong Province to integrate production resources from multiple high-quality manufacturers. This allows us to offer a wide range of sourcing options—covering various product categories and origins—instead of simply pushing a single product. Furthermore, our core competitiveness lies in our professional foreign trade services (covering documentation, logistics, and regulatory compliance), ensuring a smooth and worry-free procurement process for you.
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A: We strictly adhere to international trade rules (Incoterms® 2020) and accept various payment methods, such as Letters of Credit (L/C) and Telegraphic Transfers (T/T). For new clients, we support small-batch trial orders and can clearly define arbitration clauses and applicable laws within the contract. Additionally, we maintain a robust risk management system to help you mitigate common trade risks, such as exchange rate fluctuations, shipping delays, and document discrepancies.
Q3: Do you have experience serving clients in Russian-speaking regions?
A: Yes. We place great importance on the Russian-speaking market; our team includes Russian-speaking business professionals who are well-versed in the import regulations of Russia and the Eurasian Economic Union (EAEU). We understand the importance of EAC certification to clients in these regions and can assist with related compliance inquiries. We have established connections with chemical traders across various CIS countries and have gained valuable experience in specialized packaging and temperature-controlled shipping designed to withstand harsh local winter conditions.
Q4: How do you guarantee product quality?
A: We implement a strict supplier qualification and periodic audit system. A Certificate of Analysis (COA)—issued by the original manufacturer—is provided with every shipment. We also welcome pre-shipment inspections conducted by internationally recognized third-party agencies such as SGS, BV, or ITS. Should the test results fail to meet the standards specified in the contract, you have the right to reject the goods or request a replacement.
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