Shikimic acid CAS#138-59-0

High Water Solubility for Easy Formulation: As a white crystalline powder that dissolves readily in water, shikimic acid is convenient for processing and formulation in pharmaceutical and biochemical applications.


Naturally Derived from Renewable Plant Sources: Extracted mainly from star anise, Liquidambar fruits, and pine needles, it is a plant-based compound that meets the growing demand for natural and sustainable raw materials.


Biologically Important Metabolite: As a key metabolite in plants and microorganisms, shikimic acid plays an essential role in biochemical pathways, making it highly valuable for pharmaceutical synthesis and research.


Multiple Reliable Extraction Sources: The availability of several botanical sources ensures stable supply options and supports large-scale industrial production.



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Product Description

Product Description of Shikimic acid CAS#138-59-0

Shikimic acid is a white crystalline solid that dissolves readily in water. It was named after Japanese shikigrass, the plant from which it was first isolated. As an important metabolite found in plants and microorganisms, shikimic acid plays a key biological role. Traditionally, it has been primarily obtained from the dried mature fruits of Illicium species, commonly known as Japanese aniseed. In recent years, additional extraction sources have been reported, including the fruits of Liquidambar formosana and pine needles.


Product Application of Shikimic acid CAS#138-59-0

Shikimic acid serves as an important precursor in the synthesis of various alkaloids, aromatic amino acids, indole derivatives, and chiral pharmaceuticals. In recent years, it has been widely used as the starting material for the production of oseltamivir (the active component of Tamiflu), a neuraminidase inhibitor employed in the treatment and prevention of influenza A and influenza B.

It is also applied in the development of antitumor agents and functions as a key intermediate in the synthesis of anticancer drugs such as dioxin derivatives and glyoxalase inhibitors.

In addition, shikimic acid is used as a reference standard for the quantitative analysis of shikimic acid content in root apex tissues, and as a substrate in shikimic acid kinase activity assays.


Product Information

Parameters


Melting point185-187 °C (lit.)
Alpha-180 º (c=4, H2O 25 ºC)
Boiling point225.11°C (rough estimate)
Density1.52 g/cm3 (27.2℃)
Vapor pressure0Pa at 25℃
Refractive index-180 ° (C=1, H2O)
Storage temp.2-8°C
Solubility180g/l
FormPowder
PkapK (14.1°) 5.19
ColorWhite to light beige or light gray
Optical activity[α]/D -180.0±5.0°, c = 4 in H2O
Water Solubility18 g/100 mL (20 ºC)
SensitiveHygroscopic
Merck148480
BRN4782717
InChIKeyJXOHGGNKMLTUBP-HSUXUTPPSA-N
LogP-1.5 at 21℃ and pH1
Surface tension49.86mN/m at 1g/L and 20℃
CAS DataBase Reference138-59-0(CAS DataBase Reference)
NIST Chemistry ReferenceShikimic acid(138-59-0)
IARC3 (Vol. 40, Sup 7) 1987
Hazard CodesXi
Risk Statements36/37/38
Safety Statements22-24/25-36-26
WGK Germany3
RTECSGW4600000
F45726
HS Code29181980
Hazardous Substances Data138-59-0(Hazardous Substances Data)
ToxicityLD5 i.p. in mice: 1000 mg/kg (Evans, Osman)


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